An integrated metabolomic and proteomic approach for the identification of covalent inhibitors of the main protease (Mpro) of SARS-COV-2 from crude natural extractsArticle Published on 2023-01-152022-11-15 Journal: Talanta [Category] SARS, 유전자 메커니즘, 치료제, [키워드] Analysis applied approach baicalein binding carried catalytic characteristic Chinese complementary complex Compound Covalent binder Cys145 database drug target electrophilic Final functional HIS163 HIS164 His41 independent inhibitor inhibitors Ion knowledge M pro M(pro) mass mass spectrometry maturation metabolomic metabolomics Michael molecular dynamics MPro nucleophilic peptide platform polyprotein protease protein-ligand Proteins proteomic proteomics residue SARS-CoV-2 SARS-CoV-2. Scutellaria baicalensis tested the SARS-CoV-2 [DOI] 10.1016/j.talanta.2022.123824 PMC 바로가기
Saliva metabolomic profile of COVID-19 patients associates with disease severityArticle Published on 2022-10-222022-11-15 Journal: Metabolomics [Category] COVID19(2023년), SARS, 바이오마커, 치료기술, [키워드] 5-aminolevulinic acid Asymptomatic Biomarker Biomarkers C-reactive protein cellular change changes changes in Comparisons controls Coronavirus disease 2019 correlated COVID-19 COVID-19 group COVID-19 patient COVID-19 patients D-dimer diagnostic Disease progression disease severity dysregulation early stage expected Infection intensity Level liquid liquid chromatography-mass spectrometry metabolite metabolomic metabolomics Mild moderate molecular non-infected non-severe patients parameter Patient physiological plasma positively correlated profile prognostic prognostic biomarker risk Saliva Saliva. SARS-CoV-2 screened severity significantly sphingosine stages utility were used [DOI] 10.1007/s11306-022-01936-1 PMC 바로가기
Metabolomics-based investigation of SARS-CoV-2 vaccination (Sinovac) reveals an immune-dependent metabolite biomarkerArticle Published on 2022-09-282022-11-15 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 변종, 진단, [키워드] analyses Analysis antibodies and cytokines antibody association AUC Biomarker boost butanoate collected COVID-19 COVID-19 vaccine Cytokines determine effective fatality FDR Fold change GABA Glutamate greater help Host host immunity IgA IgG IgM immune Immunity IMPROVE individual indole Infection L-glutamic acid metabolism metabolite metabolome metabolomic metabolomic analysis metabolomics mutant strain mutated Pathways positive pre-vaccination provide respond reveal SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 virus infection sera serum serum antibody serum. Sinovac Spread Taurine vaccination Vaccine VIP Volunteer was performed [DOI] 10.3389/fimmu.2022.954801 PMC 바로가기
Metabolic and Proteomic Profiles Associated with Immune Responses Induced by Different Inactivated SARS-CoV-2 Vaccine CandidatesArticle Published on 2022-09-132022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome Affect Amino acid association candidate cellular immunity change changed composed coronavirus COVID-19 creating Delta Epidemic immune immune responses immunized mice Inactivated vaccine Inactivated Vaccines induce induced metabolic metabolism metabolomic metabolomics mice neutralizing antibody positive profile Protein proteomic proteomics response resulting SARS-CoV-2 Vaccine vaccine candidates Vaccine design Vaccines Vaccines. variant variants Variation virus [DOI] 10.3390/ijms231810644 PMC 바로가기
Serum metabolomic abnormalities in survivors of non-severe COVID-19Research article Published on 2022-09-012022-10-05 Journal: Heliyon [Category] 바이오마커, [키워드] abnormality amino acids approaches association Biomarker Care changes in characteristic consequence COVID-19 COVID-19 survivors discharge Fatty acid Health Health consequences Health status highlight Host identify Infection Inflammatory responses information Intervention Kynurenine pathway lipid metabolism Liver injury mental health metabolic metabolic abnormalities Metabolic abnormality metabolism metabolomic metabolomics non-severe patients predominant purine returned SARS-COV-2 infection serum Spread survival survivor Survivors therapeutic target triggered virus Wuhan, China [DOI] 10.1016/j.heliyon.2022.e10473 [Article Type] Research article
Combining metabolome and clinical indicators with machine learning provides some promising diagnostic markers to precisely detect smear-positive/negative pulmonary tuberculosis대사체와 임상 지표를 기계 학습과 결합하면 도말 양성/음성 폐결핵을 정확하게 감지하는 몇 가지 유망한 진단 마커를 제공합니다.Article Published on 2022-08-252022-09-11 Journal: BMC Infectious Diseases [Category] Coronavirus, 바이오마커, 치료기술, [키워드] Amino acid Analysis best Biomarker Biomarkers cause Characteristics Combination conducted Control controls COVID-19 death death case death cases detect Diagnosis diagnostic diagnostic biomarker Diagnostic biomarkers discriminant analysis dysfunction enriched pathways fatty Fatty acid feature global pandemic high accuracy Infectious disease machine machine learning marker metabolisms metabolite metabolome metabolomic metabolomic analysis metabolomic profiling metabolomics Mycobacterium tuberculosis Mycobacterium tuberculosis (Mtb) offer Patient patients performed plasma Precision provide pulmonary tuberculosis R package random Random forest Seven significant enrichment smear Smear-positive/negative pulmonary tuberculosis Support SVM TB patient three group three groups Tuberculosis Tuberculosis (TB). was performed [DOI] 10.1186/s12879-022-07694-8 PMC 바로가기 [Article Type] Article
Metallomic and Untargeted Metabolomic Signatures of Human Milk from SARS-CoV-2 Positive MothersObservational Study Published on 2022-08-012022-10-05 Journal: Molecular nutrition & food research [Category] COVID19(2023년), SARS, 임상, [키워드] acute respiratory syndrome alcohols Aluminium amino acids Aminoacyl-tRNA Concentration conducted Conjugates control group coronavirus COVID-19 derivatives difference element elements Fatty acid Health Human human milk implication increase Infection information metabolite metabolomic metabolomics metabolomics. milk mother pathway peptides plasma positive profile provide purine quantification recorded reduce Research SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection signature significantly symptomatic and asymptomatic tyrosine unique with COVID-19 [DOI] 10.1002/mnfr.202200071 PMC 바로가기 [Article Type] Observational Study
Metabolic signatures in human follicular fluid identify lysophosphatidylcholine as a predictor of follicular development Research Published on 2022-07-292022-10-05 Journal: Communications Biology [Category] 바이오마커, [키워드] analyzed Biomarker Blood can be used Characteristics clinical implications described developmental first stage follicular Follicular fluid Health humans identify immunoassay improvement independent knowledge lysophosphatidylcholine metabolic metabolomic metabolomics Oocyte ovarian participant Participants Potential biomarker predictor Regulation sensitivity serum stages Study design therapeutic target transcriptomic data [DOI] 10.1038/s42003-022-03710-4 [Article Type] Research
Targeting ACLY efficiently inhibits SARS-CoV-2 replicationACLY를 표적으로 SARS-CoV-2 복제를 효율적으로 억제Article Published on 2022-07-112022-09-11 Journal: International Journal of Biological Sciences [Category] COVID19(2023년), SARS, 변종, [키워드] ACLY acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyses Analysis ATP caused citrate coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Delta Factor help Host identify in vitro in vivo inhibit Intervention involved metabolome metabolomic metabolomics metabolomics. Mutation omicron pandemic public health replication of SARS-CoV-2 required SARS-CoV-2 SARS-CoV-2 replication severe acute respiratory syndrome Coronavirus susceptibility targeting targets Therapeutics Transmissibility Treatment Vaccine variants variants of concern virulence virus replication VOCs wild-type [DOI] 10.7150/ijbs.72709 PMC 바로가기 [Article Type] Article
Integrative metabolomic and proteomic signatures define clinical outcomes in severe COVID-19Research article Published on 2022-06-172022-10-05 Journal: iScience [Category] 바이오마커, 임상, [키워드] analysis Biological sciences Clinical finding Clinical outcome clinical outcomes collagen Concordance controls Coronavirus disease-19 COVID-19 COVID-19 disease severity COVID-19 patient cross talk disease global healthcare Hospitalized human metabolism immune modulation independent datasets Interaction Medicine metabolism metabolite metabolomic metabolomics molecular morbidity morbidity and mortality Mortality nucleotide outcome measure pandemic pathogenic performed Physiology predict predictive power Protein proteomic serum severe COVID-19 severe disease vascular homeostasis [DOI] 10.1016/j.isci.2022.104612 [Article Type] Research article